منابع مشابه
International Chronic Ocular Graft-vs-Host-Disease (GVHD) Consensus Group: Proposed Diagnostic Criteria for Chronic GVHD
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Chronic graft-versus-host disease (GVHD) is a frequent but highly polymorphic complication of allogeneic stem cell transplantation. Its clinical presentation varies from few lichenoid skin lesions to a highly aggressive disease with multiple organ involvement mimicking autoimmune diseases such as scleroderma. Since its first clinical description in 1980,1 clinicians have tried to characterize t...
متن کاملHY antibodies as biomarkers for chronic GVHD.
The therapeutic effect of allo-HCT is often complicated by GVHD due to a strong donor alloimmune response against patients’ healthy tissues. Although acute GVHD can be life threatening in the first months after HCT, cGVHD remains the major cause of long-term morbidity and NRM. Traditional cGVHD therapy with corticosteroids is not always effective, and alternative strategies based on more powerf...
متن کاملEqual opportunity targeting in chronic GVHD.
In this issue of Blood, studies by Rangarajan et al comprehensively analyzing the clonotypic T-cell response provide evidence that the effector T cells that mediate chronic GVHD may have a unique specificity that includes recognition of self.1 G raft-versus-host disease is the major complication that occurs after allogeneic bone marrow transplantation (BMT) and is classically thought to be the ...
متن کاملA 2-hit model for chronic GVHD.
In this issue of Blood, Dertschnig and colleagues1 demonstrate in mice that acute graft-versus-host disease (GHVD) results in a marked reduction of autoimmune receptor–expressing medullary thymic epithelial cells (Aire1 mTEC) and a decrease in the diversity of Aire-dependent tissue-restricted peripheral selfantigens (TRAs) required for effective negative thymic selection. Both of these abnormal...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2013
ISSN: 0268-3369,1476-5365
DOI: 10.1038/bmt.2013.97